DNASE1L3 was significantly upregulated in the tubulointerstitium of patients with lupus nephritis (n = 31) compared with controls (n = 8, mean difference in log2 expression = 1.1 ± 0.34–1.9, P = 0.0013) (Figure 3E). The gene discussed is DNASE1L3; the disease is lupus nephritis.