NOS2 and neoplasm: Interestingly, when we normalized to tumor NOS2 or COX2 expression (NOS2Tumor, COX2Tumor), we found significant increases in both exhausted and regulatory CD8+ T cells (CD8+TEx and CD8+TReg, respectively), as well as PDL1 and PDL1Tumor/NOS2Tumor and CD4+TReg/NOS2Tumor ratios in tumors from alive patients (Supplemental Figure 1, A–C; supplemental material available online with this article; https://doi.org/10.1172/jci.insight.193091DS1).