CD274 and neoplasm: Given that elevated tumor COX2 inhibited CD8+ T cell tumor infiltration (24, 40), correlations with other immunosuppressive mediators including CD4+ and CD8+ TReg, CD8+ TEx, as well as tumor- and CD68+ macrophage–associated PDL1 (PDL1Tumor and PDL1Macrophage, respectively) phenotypes were explored using Pearson’s correlation analysis.