This finding was corroborated in the 4T1 model, where these ratios were significantly increased following indomethacin treatment of WT and Nos2– tumor-bearing mice (Figure 7B), which showed that COX2 inhibition but not NOS2 deficiency was the primary mediator of increased CD8+ TEff/CD4+ TReg ratio. Here, NOS2 is linked to neoplasm.