Moreover, expression of STINGC206S (abolishing STING polymerization) or STINGS345A/358A (abolishing PERK-mediated STING phosphorylation) significantly attenuated the effect of DHN on tumor growth (Figure 10A), accompanied by the decrease in STING polymerization and phosphorylation detected in the same tumor samples (Figure 10, B and C). Here, EIF2AK3 is linked to neoplasm.