Pathologically, given that glycolysis-generated lactic acid is one of the major contributors to intracellular acidity in tumors (59), the induction of cytoplasmic DNA in glycolysis-dependent tumor cells under conditions such as defects in the DNA damage response, chromosomal instability, replicative stress, reactivation of endogenous retroelements, or the release of mtDNA (60) may lead to atypical STING activation to some extent. Here, STING1 is linked to neoplasm.