On the one hand, oxidative stress–induced cGAS/STING activation stimulates NLRP3 inflammasome–mediated pyroptosis in human nucleus pulposus cells (15); on the other hand, depletion of STING in renal cell carcinoma leads to caspase-8 activation and GSDMD-mediated pyroptosis (16). This evidence concerns the gene STING1 and hereditary clear cell renal cell carcinoma.