In contrast, when MMR-proficient CT-26 colorectal tumor cells were injected into BALB/c mice, shRNA depletion of UNG showed no therapeutic benefit alone, or when combined with FdU, but a beneficial effect on tumor growth and survival was observed when UNG depletion was combined with anti–PD-1 (aPD1) antibody therapy. The gene discussed is UNG; the disease is neoplasm.