Our study does differ from previous studies of FGF21 in lipodystrophy in that 1) AAV gene therapy was used to administer FGF21, 2) our model of lipodystrophy used an Adipoq-Cre driver to knock out Lmna, which is expressed specifically in adipocytes and marrow adipogenic lineage progenitors (49), 3) LmnaADKO mice were on a C57BL/6J background whereas aP2-nSREBP1c were on an FVB background, 4) LmnaADKO mice were on an HFD, and 5) we investigated effects at 22°C and 30°C housing temperatures. This evidence concerns the gene LMNA and lipodystrophy.