FGF21 and lipodystrophy: Taken together, in our model of LmnaADKO lipodystrophy, adipose tissue is required to mediate metabolic improvements after FGF21 administration at housing temperatures of 30°C, but not 22°C, which adds to the complex and at times contradictory literature on metabolic improvements with FGF21 treatment of preclinical models of lipodystrophy.