FGF21 and Insulin resistance: In conclusion, this study demonstrated that 1) FGF21/sTGFBR2 dual treatment improves metabolic dysfunction more at warmer housing temperatures, 2) FGF21/sTGFBR2 slightly improves metabolic dysfunction in lipodystrophic mice housed at 30°C but not insulin resistance, and 3) FGF21 alone improves metabolic dysfunction in lipodystrophic LmnaADKO mice housed at 22°C and decreases liver weight and fibrosis through effects on the hepatic transcriptome.