In summary, at thermoneutrality FGF21/sTGFBR2 more effectively improves metabolic parameters in HFD-fed obese mice than in HFD-fed mice with lipodystrophy, and FGF21/sTGFBR2 decreases quantity of rBMAT only in mice with diet-induced obesity. Here, FGF21 is linked to obesity due to melanocortin 4 receptor deficiency.