In GBM, protein tyrosine phosphatase 1B (PTPB1) interacts directly with IL13RA2 to mediate IL13-induced Src activation [20], resulting in activation of the transcription factor Schnurri3 and promotion of proliferation and invasion via WNT, ERK, and MMP9 [21]. The gene discussed is PTPN1; the disease is glioblastoma.