Furthermore, (Lu et al. 2008) observed that PHI induces hypomethylation of the cyclin-dependant kinase inhibitor 2A (CDKN2A, also known as p16) gene and hyperacetylation of histone H3 in myeloma cells, highlighting its dual impact on epigenetic modulation. The gene discussed is CDKN2A; the disease is plasma cell myeloma.