On the other hand, hypomethylation of oncogenes, such as retinoblastoma binding protein 6 (RBBP6) (Xiao et al. 2019), solute carrier family 34 member 2 (SLC34A2) (He et al. 2020), and lymphocyte antigen 6 complex locus K (LY6K) (Sastry et al. 2020), is frequently observed in numerous cancers, facilitating aberrant gene activation. Here, LY6K is linked to cancer.