The cytotoxic activity ofthe L1, L2, PdL1, PdL2, PtL1, and PtL2 complexes was evaluatedagainst A375 (melanoma), H292 (nonsmall cell lung cancer), and HSAEC(healthy lung epithelial) cell lines to assess their selective cytotoxicityand potential as anticancer agents. This evidence concerns the gene PDCD1LG2 and lung cancer.