PDCD1LG2 and cancer: Cancer cells with altered membrane compositions, increasedfluidity, and upregulated transport proteins may facilitate the preferentialuptake of these platinum-containing complexes, enhancing their efficacyin cancer cells while sparing healthy cells., In contrast, the lower reactivity and different electronic characteristicsof Pd­(II) could limit the activity of PdL1 and PdL2, despite their similar ligand frameworks.