These findings suggest that PdL2 disruptscellular structure, potentially impairing adhesion-dependent processes.The ability of PdL2 to reduce adhesion could be relevantin limiting metastasis, as “adhesion is the first step in theprocess of tumor cell invasion, and the formation and disassemblyof adhesion drive the migration cycle.” These findings underline the importance of the ligand’sdirectional interactions in influencing the biological activity ofthese complexes. Here, PDCD1LG2 is linked to neoplasm.