The cytotoxic activity ofthe L1, L2, PdL1, PdL2, PtL1, and PtL2 complexes was evaluatedagainst A375 (melanoma), H292 (nonsmall cell lung cancer), and HSAEC(healthy lung epithelial) cell lines to assess their selective cytotoxicityand potential as anticancer agents. The gene discussed is PDCD1LG2; the disease is melanoma.