Strikingly, (TNF+PGE2)-costimulated genes (Figure 2B, orange+yellow) highly significantly mimicked the RA C1 phenotype (p<10e-9 by Monte Carlo simulation) and recapitulated the C1 phenotype more completely than TNF/fibroblast-costimulated genes (Figure 2B, orange+red). The gene discussed is TNF; the disease is rheumatoid arthritis.