In the current study, we have defined TP genes whose expression is co-stimulated by adding PGE2 to TNF and showed that they are expressed in IL1β+ cluster 1 as defined in Kuo et al., 2019; Figure 2A–D, and in a subset of ICI-arthritis myeloid cells (Figure 2E and F). The gene discussed is IL1B; the disease is arthritic joint disease.