Recent reports by our and other laboratories showed that PGE2+TNF drive expression of EGFR ligands such as HBEGF in myeloid cells, thereby promoting proliferation and invasive behavior of synovial fibroblasts (Kuo et al., 2019), expansion of pancreatic tumors (Caronni et al., 2023), and survival and reparative capacities of intestinal epithelial cells (Zhou et al., 2022). The gene discussed is TNF; the disease is pancreatic neoplasm.