However, the TP signature was not limited to IL1β+ FCN1+ HBEGF+ cells, but instead partially extended into adjacent SPP1+, MERTK+ LIVE1-, and DC2 clusters (Figure 3); DC2s have recently been shown to have distinct homeostatic and pathogenic functions in RA (MacDonald et al., 2024). This evidence concerns the gene IL1B and rheumatoid arthritis.