INS and type 2 diabetes mellitus: This may explain observations of partial remission after insulin treatment in populations with more conventional forms of T2D (Ryan et al., 2004; Weng et al., 2008; Retnakaran et al., 2010; Retnakaran et al., 2014; Kramer et al., 2013a; Kramer et al., 2013b; Chon et al., 2018).