APOE and Alzheimer disease: Surprisingly, multiple AD-related risk loci were successfully identified by Ca-GPCA, including rs429358 and rs7412 (located in APOE), rs769449, rs4420638, rs56131196, rs12721051, and rs7256200 (APOC1), rs6857 (TOMM40), and rs12972970, rs12972156 (PVRL2) (Zhang et al. 2022a).