As another example, the 28th ranked gene was TNFRSF1B (Tumor Necrosis Factor Receptor Superfamily Member 1B), which has been shown to be overexpressed in people with DS and identified as a putative causal mediator of hypothyroidism (Sullivan et al. 2016, 2017, Li and Gong 2023). This evidence concerns the gene TNFRSF1B and hypothyroidism.