CD4 and rheumatoid arthritis: Thus, cell types 3 (CD14+ monocytes), 4 (CD4+ T cell), and 5 (CD8+ T cell) have the largest numbers of DMRs associated with RA status, confirming the critical roles of monocytes and T cells for RA development (McGarry et al. 2021, Chemin and Malmström 2023).