Lacking an internal ribosome entry site (IRES) for translation capability, its biogenesis is facilitated by the RNA-binding proteins FUS (fused in sarcoma) and eIF4A3 (eukaryotic translation initiation factor 4A3), with upstream regulation by cAMP-response element-binding protein (CREB) (13, 14). This evidence concerns the gene EIF4A3 and sarcoma.