CRYBA1 and age-related macular degeneration: Our previous studies with RPE‐specific knockout mice (Cryba1 cKO) have demonstrated that loss of βA3/A1‐crystallin leads to an age‐dependent atrophic AMD‐like phenotype characterized by drusen‐like deposits, lipofuscin accumulation (autofluorescence), large vacuoles/debris, melanosome accumulation in the RPE, inflammatory changes, photoreceptor loss, and declining retinal function (Ghosh et al. 2018; Shang et al. 2021; Zigler and Sinha 2015).