HDAC3 and age-related macular degeneration: This previously unrecognized role of βA3/A1‐crystallin in epigenetic regulation provides fundamental insights into RPE cell homeostasis and suggests that targeting the βA3/A1‐crystallin‐HDAC3 axis, particularly through modulation of InsP6 signaling or HDAC3 activity, could offer therapeutic opportunities for treating non‐exudative AMD.