These alterations in the RET protein profile in Cryba1 KO RPE cells suggest an impairment in the proper maturation and trafficking of this protein, potentially leading to compromised RPE cell survival, functionality, and retinal homeostasis, which are key aspects in the pathophysiology of AMD (Zigler and Sinha 2015). Here, CRYBA1 is linked to age-related macular degeneration.