In particular, class I, II, and III HDACs such as HDAC3, HDAC4/5, and Sirtuin 1(Sirt1), respectively, have been shown to have critical roles in transcription repression during aging and neurodegenerative diseases (Morris and Monteggia 2013; Razick et al. 2023). The gene discussed is SIRT1; the disease is neurodegenerative disease.