Although we have shown ITGB3 to play a critical role in brain metastasis in human and mouse BC models, it is also important to note that analysis of hypoxia-induced RNA-Seq and HIF-1α ChIP-Seq datasets together with a brain metastasis–selected RNA-Seq dataset (16) from MDA231-BrM2 cells identified, in addition to ITGB3, 43 other genes that overlapped all 3 datasets (Table 1). This evidence concerns the gene HIF1A and breast cancer.