In support of this conclusion, ITGB3 knockdown in MDA231 cells has been shown to inhibit bone colonization after saphenous vein injection (73) and lung colonization after tail vein injection (74); intravenous injections of ITGB3 shRNA nanoparticles blocked metastasis of MDA231 cells from breast to lungs (75); ITGB3 knockdown in 4T1 cells inhibited metastasis from breast to bone and lungs (76); and ITGB3 was identified in EVs from liver-tropic and lung-tropic cancer cells (20). The gene discussed is ITGB3; the disease is cancer.