ITGB3 was identified not only in EVs isolated from brain-tropic MDA231-BrM2 cells, but also in EVs from liver-tropic and lung-tropic BC cells, as well as EVs from liver-tropic and lung-tropic colorectal, gastric, and pancreatic cancer cells (20). The gene discussed is ITGB3; the disease is familial pancreatic carcinoma.