NUDT5 and leukemia: A few lines of evidence from us and others seem to refute this hypothesis: (a) leukemia cells generally favor the pentose phosphate pathway to produce R-5-P from glucose (30), and NUDT5-mediated hydrolysis of ADP-R is probably a minor source for this metabolite; (b) NUDT5 deletion specifically resulted in drastic reduction of purine salvage without affecting DNPS (Figure 5), even though both pathways depend on PRPP.