Given that HIV pathogenesis biomarkers are associated with EAA in the circulation and the gut (49), we calculated Spearman’s rank correlation between EAA measured using Universal Clock 3 in the solid tissues and circulating biomarkers of SIV pathogenesis, including CD4+ T cells, viral loads, T cell activation and proliferation status, inflammation, and hypercoagulation. The gene discussed is CD4; the disease is thrombophilia.