SLC25A46 and familial partial epilepsy: Conversely, AS-specific genes annotated in OMIM demonstrate predominant connections to neurological and mitochondrial mechanisms: (1) peripheral neuropathy-associated SLC25A46 mutations [29]; (2) NPRL3 variants linked to familial focal epilepsy [30]; (3) mitochondrial regulatory defects involving MT-ND2/6, SDHC, and TIMM22 [31, 32].