Prominently downregulated proteins (TUBGCP2, NPR2, MT-ATP6, SLC25A11, and so on) were enriched in cytoskeletal dynamics and cardiomyopathy pathways, while upregulated proteins (ATP6V0D2, HNRNPA1, TPM1, and so on) associated with oxidative stress responses and neurodegenerative disorders (AD and PD; Figure 3F–I). This evidence concerns the gene NPR2 and Parkinson disease.