Downregulated proteins in the aged group (TUBGCP2 and SLC25A11) were enriched in cytoskeletal dynamics and cardiomyopathy pathways, whereas upregulated proteins (ATP6V0D2 and TPM1) associated with oxidative stress and neurodegenerative disorders (Figure 3H,I). The gene discussed is SLC25A11; the disease is cardiomyopathy.