Shao et al. (62) found that the level of ALKBH5 was up-regulated in cardiac tissues of mice with diabetic cardiomyopathy and activated post-transcriptional forkhead box O3 (FOXO3) in an m6A-YTHDF2-dependent manner, leading to an increased level of cardiomyocyte apoptosis. Here, FOXO3 is linked to diabetic cardiomyopathy.