TNF and myocarditis: Similar to the results of this study, reduced expression of FTO has also been found in myocardial tissues of mice with myocardial inflammation, and FTO knockdown can lead to hypermethylation of mRNA transcripts of inflammatory cytokines, resulting in an increase in the levels of inflammatory factors such as interleukin-6 (IL-6), tumor necrosis factor α (TNF-α), and interleukin-β (IL-1β) (80).