Subsequently, in our cohort, we conducted an exploration of the TLR4/MyD88 signaling axis in the pathological process of HFpAMI using RT-qPCR methods, revealing significantly elevated expression levels of TLR4 and MYD88 in PBMC samples from the HFpAMI group compared to the non-HF group. This evidence concerns the gene MYD88 and hydrops fetalis.