TMEM163 and Parkinson disease: A meta-analysis identified 18 genes (GBA, SIPA1L2, TMEM163, LAMP3, VPS13C, SNCA, LRRK2, etc.)out of 26 genetic loci across the genome associated with PD modulate ALP, indicating the indispensable role of ALP in the pathogenesis of PD (Cuajungco and Kiselyov, 2017; Cai et al., 2022; Pang et al., 2022).