A meta-analysis identified 18 genes (GBA, SIPA1L2, TMEM163, LAMP3, VPS13C, SNCA, LRRK2, etc.)out of 26 genetic loci across the genome associated with PD modulate ALP, indicating the indispensable role of ALP in the pathogenesis of PD (Cuajungco and Kiselyov, 2017; Cai et al., 2022; Pang et al., 2022). This evidence concerns the gene SIPA1L2 and Parkinson disease.