LDLR: Low-Density Lipoprotein Receptor; LDL: Low-Density Lipoprotein; FH: Familial Hypercholesterolemia; APOB: Apolipoprotein B; CAD: Coronary artery disease; PCSK9: Proprotein Convertase Subtilisin/Kexin Type 9; FBN-1: Fibrillin-1; COL3A1: Collagen Type III Alpha 1; SCN5A: Sodium Voltage-Gated Channel Alpha Subunit 5; MYH7: Myosin Heavy Chain 7; HCM: Hypertrophic Cardiomyopathy; LMNA: Lamin A and C; TTN: Titin; TTNtv: Titin-Truncating Variants. The gene discussed is PCSK9; the disease is familial hypercholesterolemia.