IL6 and ischemia: Similar results were observed for proximal tubule injury markers Havcr1 and Lcn2, as well as the distal tubule injury marker Lcn2 and the pro-inflammatory cytokines Ifng and Il6. In contrast, the ischemia-reperfusion kidney injury model (IRI) did not recapitulate changes in the genes associated with the differentiation and function of tubules and glomeruli, and most kidney injury markers were unaffected.