DSG3 and acquired polycythemia vera: Compared with Dsg3-negative PF patients, Dsg3-positive PV patients (Dsg1-Dsg3+, Dsg1+Dsg3+) were more prone to mucosal lesion, reflecting the central role of Dsg3 antibodies in mucosal damage, in agreement with the clinical consensus (Supplementary Figure 2) (3, 18).