The results demonstrated that anti-Dsg1 and anti-Dsg3, exhibited superior performance in differentiating between healthy individuals and pemphigus, with AUC values of 0.96 (95%CI: 0.93~1) for anti-Dsg1 and 0.91 (95%CI:0.86~0.96) for anti-Dsg3 (Figure 6A). This evidence concerns the gene DSG1 and pemphigus.