The positive rates of anti-Dsg1, Dsg3, BP180 and BP230 antibodies were 68.5%, 63.0%, 9.3% and 0% in patients with pemphigus, and 1.89%, 0.94%, 76.42% and 37.74% in patients with BP, respectively. This evidence concerns the gene COL17A1 and pemphigus.