IL10 and neoplasm: Interestingly, in the tumor microenvironment, disruption of OXPHOS and lipid metabolism in tumor-infiltrating Tregs has been shown to paradoxically bolster their suppressive capacity, mediated in part by type I IFN signaling and increased IL-10 production (77), also demonstrating that not all Treg suppressive functions are dependent on lipid metabolism and OXPHOS.