CD4 and Granuloma: Figure 1a provides an overview of granuloma, epitheloid cell and giant cell patterns in the H&E staining. Further immunohistological analyses comprised quantifications of CD4+ and CD8+ T-cell distributions in the perigranulomatous area, the granuloma wall and the granuloma necrosis as depicted in Figures 1b, c, which was done using QuPath version 0.5.0 (16).