The first is marked by high levels of C–C chemokines and dominance of IL-1R1, the second by a mix of TH1, TH2, TH17, and epithelial-related chemokines, the third by a TH2, TH22, and pulmonary and activation-regulated chemokine (PARC) dominance, associated with more severe disease, and the fourth by a TH2 and eosinophil-low profile, which corresponds to a milder form of AD (138). The gene discussed is CCL18; the disease is Alzheimer disease.