TP53 and head and neck squamous cell carcinoma: In the TCGA-HNSCC samples, we observed that in the high-risk group, 141 (94%) HNSCC patients out of 150 samples showed high-frequency mutations top 10 genes, of which the top 3 mutated genes were TP53 (73%), TTN (39%) and FAT1 (26%) (Figure 4A).