In contrast, the top 10 mutated genes in HNSCC patients showed mutations in 315 out of 344 samples (91.57%) in the low-risk group, with TP53 as the gene with the most mutations of 65% in the samples, followed by TTN and FAT1 in 39% and 21% respectively (Figure 4B). Here, TP53 is linked to head and neck squamous cell carcinoma.