IL6 and myeloid sarcoma: Supporting the organic theory, neuroinflammatory mediators such as tumor necrosis factor (TNF)-α and interleukin (IL)-6—integral to MS pathophysiology—have been associated with the severity of anxiety and depressive symptoms in MS patients (13) as well as in experimental autoimmune encephalomyelitis (EAE), an animal model of MS (14, 15).