Modified lipoproteins, such as oxidized LDL (oxLDL), may trigger chronic inflammatory and immune responses, contributing to both cardiovascular disease and frailty through shared inflammatory markers, including interleukin‐6 (IL‐6) and tumor necrosis factor‐alpha (TNF‐α) (James et al. 2024; Engelen et al. 2022; Bielecka‐Dabrowa et al. 2020). The gene discussed is TNF; the disease is cardiovascular disorder.