HGF and cancer: Conversely, in fibrosis linked to cancer, LOX and transforming growth factor-β (TGF-β)-activated myofibroblasts secrete growth factors like HGF and FGF, which promote tumor cell viability and angiogenesis LOX’s enzymatic role extends to myelofibrosis, influencing megakaryocyte differentiation and platelet formation, and is critical for PDGF signaling and cell proliferation (107, 108).