Table 9 enumerates the top 20 co - cited references. The reference with the highest citation count was from a 2006 publication in Nature, authored by Janine T. Erler. This study delved into LOX’s role in tumor metastasis, especially its ECM - regulating mechanism for tumor invasion. Figure 5E’s keyword visualization displays nodes such as “activation”, “lysyl oxidase”, “lysyl oxidase - 2”, “gene”, “breast cancer”, “cancer”, and “extracellular matrix” connected by lines, highlighting the intricate relationships within LOX research. Here, LOX is linked to breast cancer.