Furtherly, LOX-PP expression was found to diminish the proliferative, migratory, anchorage-independent growth, and tumorigenic abilities of Ewing sarcoma in immunocompromised mice, while the C-terminal of LOX enzymatically active domain of LOX exerted opposing effects, indicating that LOX’s tumor-suppressive role is specifically attributable to its propeptide domain (41). This evidence concerns the gene LOX and Ewing sarcoma.