Additionally, lysyl oxidase (LOX) released from hypoxic breast tumor cells accumulates in premetastatic niches, cross-links type IV collagen within the basement membrane, and critically contributes to the recruitment of CD11b+ myeloid cells (36).In most cases, LOX is a pivotal factor in the restructuring of the tumor-related extracellular matrix, metastasis, and the premetastatic niche. This evidence concerns the gene ITGAM and neoplasm.