ITGAM and colorectal carcinoma: These CD11b+ cells bind to the crosslinked collagen IV and produce matrix metalloproteinase - 2, which cleaves collagen, thereby facilitating the invasion and recruitment of bone marrow - derived cells (BMDCs) and metastasizing tumor cells (46, 47).Regarding human colorectal carcinoma cell lines, the induction of LOX augmented HIF - 1 expression, whereas LOX silencing led to a reduction.