Multivariate analysis identified seven independent risk factors: age (odds ratio [OR] = 1.032, 95% confidence interval [CI]: 1.005–1.062, P = 0.021), white blood cell (WBC) (OR = 1.127, 95% CI: 1.006–1.270, P = 0.043), ankle-brachial index (ABI) (OR = 5.447, 95% CI: 2.186–14.340, P < 0.001), urine albumin-to-creatinine ratio (UACR) (OR = 2.049, 95% CI: 1.062–3.936, P = 0.031), family history of diabetes (OR = 3.405, 95% CI: 1.666–7.039, P < 0.001), diabetic peripheral neuropathy (DPN) (OR = 5.084, 95% CI: 2.673–9.805, P < 0.001), and albumin (ALB) (OR = 0.850, 95% CI: 0.786–0.915, P < 0.001). The gene discussed is ALB; the disease is diabetes mellitus.