In an experiment investigating the protection of C3G against hypercholesterolemia-induced endothelial dysfunction in apoE-deficient (apoE2/2) mice, C3G-fed mice were found to have higher expressions of ABCG1 and lower concentrations of cholesterol and 7-KC by comparing them with high-fat-cholesterol-rich diet mice (64); However, increased superoxide emission and generation over the course of hypercholesterolemia is a critical factor in the pathogenesis of endothelial function dysfunction and AS. Here, APOE is linked to familial hypercholesterolemia.