INS and type 2 diabetes mellitus: One RCT that included German, insulin-treated T2D patients showed very similar results: an average HbA1c reduction in the IG of −0.5% (p < 0.001, d = 0.18) and significant group differences in favor of the IG compared with a CG with DMP care [Mdiff: −0.2%, 95% CI (−0.36%; −0.04%), p = 0.013, d = 0.16] after 6 months (25).