RAB12 and Alzheimer disease: Similar to AD and DLB, we observed pS106-Rab12 labeling of pathological tau, in the form of neurofibrillary tangles and dystrophic neurites, in the hippocampus and temporal cortex of LRRK2GS PD cases (Braak > 3) and iPD cases (Braak > 3) (Fig. 8a).