This elevation in pS106-Rab12 labeling is consistent with our finding of age-dependent accumulation of pS106-Rab12-positive GVBs in PS19 mice as well as other work showing age-dependent accumulation of GVBs in mouse tauopathy and synucleinopathy models [22, 36, 42, 95]. This evidence concerns the gene RAB12 and synucleinopathy.