Considering both pathological α-synuclein and tau accumulation induce endolysosomal stress, and both proteins can be degraded by lysosomes, LRRK2 and Rab12 may play fundamental roles in mediating early stages of α-synuclein and tau pathology in neurodegenerative diseases [12, 34, 41, 50, 54, 66, 68, 69, 77]. This evidence concerns the gene RAB12 and neurodegenerative disease.