Mutations in leucine-rich repeat kinase 2 (LRRK2) increase its kinase activity and cause autosomal dominant Parkinson’s disease (PD) that clinically overlaps with idiopathic PD (iPD), but with pleiotropic pathologies [5, 26, 29, 30, 40, 63, 64, 74, 78, 83, 93, 99]. This evidence concerns the gene LRRK2 and Parkinson disease.