We also explored the LRRK2 L1165P variant which is exceedingly rare and detected in a single early-onset PD case with unclear causality, as well as a LRRK2GS subject with Schizophrenia and no PD diagnosis which was reported to have no pathology (α-synuclein or tau) [17, 32]. This evidence concerns the gene LRRK2 and Parkinson disease.