Previous studies have shown that lipolysis by PNPLA2 supports insulin secretion in beta cells.6,7,21 Interestingly, glucose responsiveness of lipolysis is blunted in human islets from T2D donors and potentially contributes to impaired beta cell function in T2D.6 Thus, the current study aimed to determine a factor that mediates the increase of lipolysis by glucose in beta cells. This evidence concerns the gene PNPLA2 and type 2 diabetes mellitus.