Studying variation in the sensitivity to Orsay virus infection among wild C. elegans strains, we previously found that a 159 bp natural deletion allele (niDf250) in the RIG-I like domain of DRH-1 was causally associated with hypersensitivity to viral infection and was present at an intermediate frequency in the species (Ashe, Bélicard, Le Pen, Sarkies et al., 2013) (Fig. 3A). This evidence concerns the gene RIGI and viral infectious disease.