Similar to what we have reported on the acute stage of stroke [30], old mice have larger atrophy volume (p = 0.004, Supplementary Fig. 6), and more CD68+ cells in the peri-atrophic (p<0.001) and hippocampal regions ipsilateral to stroke injuries than young stroke mice (p=0.009, Supplementary Fig. 7) as well as more CD68+ cells in the ipsilateral hippocampi than the contralateral hippocampi (p<0.001, Supplementary Fig. 7). This evidence concerns the gene CD68 and Stroke.