In this study, we found that old mice developed long-lasting memory dysfunction, which was also associated with more CD68+ activated microglia/macrophages and GFAP+ reactive astrocytes in the peri-atrophic regions and hippocampi than young stroke-only mice at 8 weeks after stroke injury (Supplementary Figs. 7, 8, & 9). The gene discussed is CD68; the disease is Stroke.