To functionally evaluate the immunogenicity of TSCs in vivo and to demonstrate that lymphocytes mediate the control of TSC tumors in an intact immune system we implanted TSCs and TRPCs into the brains of Fox Chase SCID mice, which are deficient in both T and B cells, and CD8-Knock Out (KO) mice, which specifically lack CD8+ T cells. Here, CD8A is linked to tuberous sclerosis.