TEMRA cells can have effector functions such as cytotoxicity and are associated with cell senescence in aging (59, 60); however, we observed an increased proportion of CD8+ GZMK+ IFNG+ T cells in EM lesions from all study participants (age range 31–76, median 68), indicating that their presence was not a function of aging per se. This evidence concerns the gene CD8A and erythema multiforme.