Several studies already reported lack of TDP-43 abnormalities in mutant SOD1 transgenic mice.40,41 Since TDP-43-cKO mice have reduced Neat1 expression in the motor neuron without TDP-43 as described above, we refrained from using TDP-43-KO mice as ALS model mice in this experiment. The gene discussed is NEAT1; the disease is amyotrophic lateral sclerosis.