These findings suggest the primary bioactive components of THSW Decoction (ferulic acid, p-hydroxycinnamic acid, 3-hydroxy-4-methoxycinnamic acid, ferulaldehyde, and vanillic acid) may inhibit liver fibrosis by modulating JUN, PTGS2, BCL2, ESR1, and PPARG. The gene discussed is ESR1; the disease is Hepatic fibrosis.