Inhibition of CK1γ by these analogues provides a novel approach to cancer treatment by disrupting downstream transcriptional activation of cell survival genes.20 In a separate study, Bhat et al. investigated 4-aryl-5-(pyridin-4-yl)-3H-1,2,4-triazole-3-thiones and reported that compound 3j induced apoptosis in cancer cells via caspase-3 activation. This evidence concerns the gene CASP3 and cancer.