Six months of voluntary wheel running significantly downregulated the expression of Ferritin, HO-1, janus kinase 1 (JAK1), signal transducer and activator of transcription 3 (STAT3), DMT1, TFR, and hepcidin in the cerebral cortex of five familial Alzheimer’s disease (5×FAD) mice, reduced Aβ and IL-6 levels, inhibited Aβ plaque deposition and neuroinflammation, thereby improving neurological deficits in AD mice (Belaya et al., 2021). Here, STAT3 is linked to Alzheimer disease.