Neuritin significantly upregulated the expression of microtubule-associated protein 2 (Map2), neuronal nuclei (NeuN), and postsynaptic density protein 95 (PSD95) in the hippocampus of Amyloid precursor protein (APP)/Presenilin 1 (PS1) transgenic AD mice. The gene discussed is DLG4; the disease is Alzheimer disease.