In vivo, TIGAR overexpression markedly increases NADPH, GPX4, and GSH levels in the substantia nigra of MPTP-induced PD mice, reduces Fe2+, MDA, and ROS levels, inhibits dopaminergic neuronal ferroptosis, and improves neurological function (Sheng et al., 2025). The gene discussed is TIGAR; the disease is Parkinson disease.