In vivo, FTO knockdown significantly elevates YTHDF2 expression in the striatum of PD mice, inhibits m6A demethylation of BAP1 and reduces BAP1 expression, upregulates SLC7A11 expression, decreases α-Syn, MDA, Fe2+, and 4-HNE levels, suppresses neuronal ferroptosis and disruptions in the amino acid antioxidant system, and promotes dopaminergic neuronal survival in PD mice (Li et al., 2025c). This evidence concerns the gene BAP1 and Parkinson disease.