And other therapeutic target is BIRD-2, which also targets the BH4 domain of Bcl-2, has defined that causing the Ca2+ overload and opening the mPTP, resulting the death of the diffuse large b-cell lymphoma (DLBCL) and chronic lymphocytic leukemia (CLL) cell (Kerkhofs et al., 2021). The gene discussed is BCL2; the disease is B-cell chronic lymphocytic leukemia.