Notably, the interaction networks formed by miRNA, protein, and metabolite fingerprints involved in the early stage of DCM such as hsa-mir-122-5p, IL6, FGL1, LEP, ADIPOQ, INS, TNF, IGFBP7, GDF15, GPX3, NPPA, bilirubin, butyric acid (butyrate), and creatinine are the potential biomarkers for the early stage of DCM and also may be the therapeutic targets for the early stage of DCM. Here, NPPA is linked to familial dilated cardiomyopathy.