The concentration of annexin A2, which is a calcium-dependent phospholipid-binding protein, was found to be higher in the serum of DCM patients, in a study from China, and was negatively associated with systolic and diastolic functions of the heart, and this may help in early diagnosis of DCM (He et al., 2023). The gene discussed is ANXA2; the disease is familial dilated cardiomyopathy.