The downregulation of miR-30c and miR-181a expressions was associated with an increase in the myocardial expression of p53 and p21, suggesting these miRNAs have a synergistic effect on p53-p21 pathways in cardiac hypertrophy induced by diabetes, as found from a study in India (Raut et al., 2016). Here, TP53 is linked to diabetes mellitus.