Likewise, in cancer cell migration, while CXCL12 (Guo et al., 2016; Luo et al., 2019; Hayasaka et al., 2022) and Ephrin (Campbell et al., 2006; Wang, 2011; Cho et al., 2018) signalling have been linked to metastasis, the specific role on invasive behaviour of their local signalling at the ciliary compartment remains poorly characterised. Here, CXCL12 is linked to cancer.