The transmembrane Frizzled-like receptor Tmem67/MKS-3, a transition zone protein that functionally binds Wnt5a (Abdelhamed et al., 2015) and whose mutations are responsible for the MKS and JBTS ciliopathies, has moreover been located to the PC base of the C. elegans ciliated sensory neurons (Williams et al., 2010). The gene discussed is TMEM67; the disease is Joubert syndrome.