Extracellular vesicles are important mediators of the transfer of active substances and genetic information between cells, and are involved in the development of sleep disorders and their subsequent resultant cognitive deficits by increasing the formation of amyloid plaques, transmitting tau proteins, modulating neuroinflammation, and increasing the permeability of the blood-brain barrier (Gu and Zhu, 2021). Here, MAPT is linked to sleep disorder.