For instance, high expression of POLR2J4 has been reported to be associated with poor prognosis in various malignancies (Lu et al., 2019; Wu et al., 2023), while SNHG16 promotes glioma tumorigenesis via activation of the PI3K/AKT pathway and the miR-373/EGFR axis (Zhou et al., 2020). This evidence concerns the gene POLR2J4 and central nervous system cancer.