PAK5 and central nervous system cancer: LncRNA AC004943.2 may contribute to tumor progression through regulation of the miR-135a-5p and PTK2/PI3K axis (Zhu et al., 2024), while SOX21-AS1 enhances glioma cell proliferation and invasion by sponging miR-144-3p to upregulate PAK7 expression (Gai and Yuan, 2020).