In the univariate Cox regression analysis, age (p < 0.001, HR = 1.066 [1.045–1.086]), gender (p < 0.001, HR = 3.219 [1.836–5.643]), IDH status (p < 0.001, HR = 8.450 [5.021–14.220]), 1p/19q co-deletion (p < 0.001, HR = 0.274 [0.139–0.541]), MGMT promoter status (p < 0.001, HR = 3.050 [1.807–5.148]), and risk score (p < 0.001, HR = 1.399 [1.301–1.504]) were found to be significantly associated with the overall survival (OS) of glioma patients. This evidence concerns the gene MGMT and central nervous system cancer.